Assignment Example | Topics and Well Written Essays - 500 words - 45

Assignment Examplenserved proteins responsible for the maintenance of the conformational homeostasis of cellular proteins and RNAs and be believed to be usually induced by environmental stress (Soti & Csermely, Molecular Chaperones 227). In short, as molecular chaperones be often associated with aging tissues and aging in general, these proteins are especially found in such situations. There is, however, a arguing whether their presence in the aging tissue is merely induced or it is this presence that induces aging. Hsp60 is involved in protein folding and hsp70 has a role in the ordinance the heat shock response as well as membrane translocation. While hsp60 are found in the mitochondria, hsp70 is found in the eukaryotic cytosol, ER and mitochondria. Both families of proteins actually function for protein translocation and transport as well as folding and assembly (Molecular Chaperones). In aging and diseased tissues, high amounts of hsp60 are found in people with atherosclerosi s, acute coronary syndromes and angina, while hsp70 is found in those with peripheral as well as renal vascular diseases (Frostegard & Pockley 201-202).A number of experts and experiments in the field of molecular biology are pointing out that chaperones are the ones that bring about the aging process at the molecular level. Soti and Csermely, in their study entitled Chaperones and aging role in neurodegeneration and in other civilizational diseases, underlined the possibility that HSPs might contribute to the onset ofatherosclerosis, cancer, diabetes and several neurodegenerative diseases (384). In an actual observational study in Korea, it was confirmed that the HSPs might be involved in tumorigenesis as it did in patients with hepatocellular carcinomas (Lim et al. 2077). This is so because, as proven by rodent experiments, HSPs are known to be essential for the survival of cancer cells in different cancers (Lim et al. 2077). Moreover, one particular HSP, hsp90,